His son, James Macdonald, studied medicine with Dr. David Palmer, of White Plains, and Dr. David Hosack, of New York. As an investigator of insanity, in the ti'eatment of which he became an expert, he visited the principal lunacy asylums of Europe; and, on his return to this country, was one of the founders and proprietors of the Sanford Hall Asylum, at Flushing, L. I. He died in 1849, leaving his brother, Allen Macdonald, in charge of that institution.

Dr. Stephen Fowler, a native of Orange County, N. Y., practiced in New Castle, Westchester County, eight years previous to his death, which occurred in 1814, when he was but thirty-five years of age. Despite his youth, he was quite successful, and accumulated in that short time a moderate fortune. He died from typhoid pneumonia, which was then epidemic in the neighborhood. Dr. Joshua W. Bowron was one of his students, and upon his death located in the immediate vicinity of his office.

Dr. Donal, ofColaburg (now Croton),on the Hudson, was a young man who began practice in 1814, during the prevalence of typhoid pneumonia, and won much praise for his successful treatment of the disease by the stimulating plan. He removed to New York and died there.

Dr. Clark Sanford resided at Greenwich, Conn., but for thirty years prior to his death, in 1820, when he was over sixty years old, had a wide professional connection in Westchester County. He was a native of Vermont, and the manufacturer of a superior article of pulverized Peruvian bark. His grinding-mills were at Byrom's Mills, now called Glenville; they were the first establishment of the kind in the United States, and his son John continued and enlarged the business with great profit. He is spoken of as " a bold practitioner of both medicine and surgery." He was a very eccentric man and an inveterate smoker, always carrying his pipe between his lips or in his boot leg.